UK Prescribing Information
Prof. Olivier Rascol
University Hospital of Toulouse & University of Toulouse, Toulouse, France
Discussion open and introduction
Prof. Rascol provides an overview of the progression of clinical symptoms associated with PD, in addition to the current treatment options including the place of COMT inhibitors.1/6 Next Chapter
The biology of levodopa and the role of COMT inhibitors in levodopa pharmacokinetics
Prof. Jenner describes the challenges in delivering levodopa to the brain, and the pharmacological properties of COMT inhibitors and their effect on levodopa concentrations.2/6 Next Chapter
Differentiating COMT inhibitors and the clinical development of opicapone for fluctuating Parkinson’s disease
Prof. Ferreira presents key results from clinical trials investigating the effect of opicapone on motor fluctuations, along with how these results compare with other PD treatments.3/6 Next Chapter
The role of opicapone in the treatment of early motor fluctuations
The panel discuss usual approaches to treating patients with early-stage motor fluctuations, and how a recent analysis and an ongoing trial may change COMT inhibitor positioning in the treatment of PD.4/6 Next Chapter
The role of opicapone in the treatment of non-motor symptoms
The panel discuss the impact of non-motor symptoms on patients with PD, and the potential role of COMT inhibitors in managing these symptoms based on previous and ongoing clinical trials.5/6 Next Chapter
Conclusions and close
Prof. Rascol provides a summary of the demonstrated efficacy and safety of opicapone in PD, including in patients with recently diagnosed motor fluctuations and non-motor fluctuations.6/6 Leave Feedback
Learning Objectives & Overview
In Parkinson’s disease, the once-daily COMT inhibitor, opicapone, increases the bioavailability of levodopa, decreasing motor fluctuations.1–3 In this activity, leading experts discuss the challenges in delivering levodopa to the brain, key results from clinical trials investigating the effect of opicapone on motor fluctuations, and ongoing trials assessing opicapone in early-stage motor fluctuations, and non-motor symptoms.
After watching this activity, participants should be better able to:
- Discuss the clinical trials examining the effects of opicapone in treating patients with PD and motor fluctuations, their key results and implications.
- Describe the clinical studies investigating the early intervention with COMT inhibitors in patients with early motor fluctuations, and their results.
- Understand the potential of opicapone to treat non-motor symptoms, including the design of ongoing trials investigating these outcomes.
Faculty & Disclosures
Prof. Olivier Rascol
University Hospital of Toulouse & University of Toulouse, Toulouse, France
Has participated in clinical trials sponsored by Bial and have received honoraria for consultancy and advisory boards from Bial; has acted as a scientific advisor for drug companies developing antiparkinsonian medications (Abbott, Abbvie, Acorda, Adamas, Affiris, Biogen, Britannia, Cynapsus, Denali Pharmaceuticals, Impax, Lundbeck, Merck, Neuroderm, Novartis, Orian Pharma, Osmotica, Oxford-Biomedica, Prexton, Servier, Sunovion, TEVA, UCB, Zambon) and has received unrestricted scientific grants from academic non-profit entities (Toulouse University Hospital, French Health Ministry, MJFox Foundation, France-Parkinson, European Commission EU FP7, and Horizon 2020).
Prof. Peter Jenner
King’s College London, London, UK
Has received honoraria for consultancy and advisory boards from AbbVie, Adamas, Bial, Britannia Pharmaceuticals, FP Pharmaceuticals, Kyowa Kirin, Roche, UCB, Worldwide Clinical Trials, Zambon, Chiesi Pharmaceuticals, and Profile Pharma.
Prof. Joaquim Ferreira
Universidade De Lisboa, Lisboa & CNS – Campus Neurológico, Torres Vedras, Portugal
Has participated in clinical trials sponsored by Bial and have received honoraria for consultancy and advisory boards from Bial; has received grants from GlaxoSmithKline, Grunenthal, Fundação MSD (Portugal), TEVA, Allergan, Novartis, Medtronic and consultancy fees from GlaxoSmithKline, Novartis, TEVA, Lundbeck, Solvay, BIAL, Merck-Serono, Merz, Ipsen, Biogen, Acadia, Allergan, Abbvie, Sunovion Pharmaceuticals, Zambon, Neuroderm, and Affiris.
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- Lees AJ, Ferreira J, Rascol O, et al. Opicapone as Adjunct to Levodopa Therapy in Patients With Parkinson Disease and Motor Fluctuations: A Randomized Clinical Trial. JAMA Neurol. 2017;74(2):197–206.
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